Bimatoprost (marketed in the U.S., Canada and Europe by Allergan, under the trade name Lumigan) is a
prostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the
management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid
from the eyes. It has also been used and prescribed off-label to lengthen eyelashes. In December 2008, this
use was approved by the U.S. Food and Drug Administration (FDA); the cosmetic formulation of bimatoprost is sold as
Latisse ( /ləˈtiːs/). Recently,[when?] at least three case series have suggested that bimatoprost has the
ability to reduce adipose (fat) tissue.
1 Cosmetic use
2 Fat-reducing properties
5 Side effects
8 External links
In patients using ophthalmic prostaglandins such as travoprost and latanoprost, as well as prostamides like
bimatoprost, it has been anecdotally noted[by whom?] that there had been an increase in diameter, density and
length of eyelashes. Allergan has initiated[when?] clinical trials investigating the usage of Lumigan as a cosmetic
drug. On December 5, 2008, the FDA Dermatologic and Ophthalmic Drugs Advisory Committee voted to approve
bimatoprost for the cosmetic use of darkening and lengthening eyelashes. The medical term for this
is treatment of hypotrichosis, however, the FDA approval is for purely cosmetic purposes.
According to Allergan's package labeling, users of its Latisse cosmetic product didn't develop darker irises in
clinical studies; however, "patients should be advised about the potential for increased brown iris pigmentation
which is likely to be permanent."
Several cosmetics companies have released products based on prostaglandin analogs, as non-drug cosmetics.
Age Intervention Eyelash by Jan Marini Skin Research
RevitaLash by Athena Cosmetics Corp.
MD Lash Factor by PhotoMedex Inc.
These companies have been sued by Allergan for patent infringement. The FDA has seized Age Intervention Eyelash
as an "unapproved and misbranded drug" because Jan Marini Skin Research promoted it as something that increases
eyelash growth and because it is "adulterated" with bimatoprost.
Reductions in orbital fat (i.e., fat around the eye) have been observed in patients using bimatoprost as
glaucoma therapy. Of particular interest, the loss of orbital fat was unilateral in patients who used
bimatoprost on only one eye. The effect appears reversible upon cessation of bimatoprost use.
The effect is likely to explain deepening of the lid sulcus described in a series of three patients on
bimatoprost. The mechanism for the apparent fat reduction remains unclear. However, bimatoprost is chemically
analogous to prostaglandin F2 alpha (PGF2alpha), a compound which is known to reduce fat by inhibition of adipocyte
differentiation and survival.
Latisse price and cost are wonderful at www.latisse.bz
Lumigan is a 0.03% solution of bimatoprost, and contains benzalkonium chloride as a preservative. Contact lenses
should therefore be removed before use, and replaced no less than 15 minutes later; other eye drops or ointments
should be given no less than five minutes before or after bimatoprost. It is administered once daily.[citation
Studies have shown once-daily bimatoprost 0.03% ophthalmic solution to be more effective than timolol twice
daily in reduction of intraocular pressure (IOP) and as effective as or more effective than the prostaglandin
analogues latanoprost and travoprost in reducing IOP.
Possible side effects of this medication are:
May cause blurred vision.
May cause eyelid redness.
May permanently darken eyelashes.
May cause eye discomfort.
May eventually cause permanent darkening of the iris to brown.
May cause a temporary burning sensation during use.
May cause thickening of the eyelashes.
It may cause unexpected growth of hair if applied inappropriately, on the cheek, for example.
It may cause infection if the one-time applicators which come with the genuine product are reused.
Lashes may grow so long that they become ingrown and scratch the cornea.
May cause darkening of the eyelid or of the area beneath the eye.
On November 19, 2007, the FDA issued a warning during the seizure of a bimatoprost-containing cosmetic. The
warning stated that "the extra dose of bimatoprost may decrease the prescription drug's effectiveness. Damage to
the optic nerve may lead to decreased vision and possibly blindness."
^ a b c "Bimatoprost Ophthalmic". MedlinePlus. January 1, 2003. Archived from the original on 2007-10-05.
^ a b c Rundle, Rhonda L. (2007-11-19). "Drug That Lengthens Eyelashes Sets Off Flutter". The Wall Street Journal.
^ "Allergan gets FDA approval for eyelash treatment". BusinessWeek. Associated Press. December 26, 2008. Retrieved
December 26, 2008.
^ The Pink Sheet:  Lauren Smith December 15, 2008; Volume 70, Number 050,Page[verification needed]
^ Latisse prescribing information: "Important Safety Information"
^ MSNBC: FDA Seizes $2 Million Of Potentially Harmful SJ Eye Product KNTV-TV November 17, 2007[dead link]
^ Reuters: "U.S. seizes discontinued eyelash product". Jim Wolf. November 16, 2007.
^ Tappeiner C, Perren B, Iliev ME, Frueh BE, Goldblum D (May 2008). "Orbitale Fettgewebsatrophie bei lokaler
Bimatoprost-Therapie - Kann Bimatoprost einen Enophthalmus verursachen? [Orbital fat atrophy in glaucoma patients
treated with topical bimatoprost--can bimatoprost cause enophthalmos?]" (in German). Klinische Monatsblätter Für
Augenheilkunde 225 (5): 443–5. doi:10.1055/s-2008-1027362. PMID 18454393.
^ Filippopoulos T, Paula JS, Torun N, Hatton MP, Pasquale LR, Grosskreutz CL (2008). "Periorbital changes
associated with topical bimatoprost". Ophthalmic Plastic and Reconstructive Surgery 24 (4): 302–7.
doi:10.1097/IOP.0b013e31817d81df. PMID 18645437.
^ Peplinski LS, Albiani Smith K (August 2004). "Deepening of lid sulcus from topical bimatoprost therapy".
Optometry and Vision Science 81 (8): 574–7. doi:10.1097/01.opx.0000141791.16683.4a. PMID 15300114.
^ Serrero G, Lepak NM (April 1997). "Prostaglandin F2alpha receptor (FP receptor) agonists are potent adipose
differentiation inhibitors for primary culture of adipocyte precursors in defined medium". Biochemical and
Biophysical Research Communications 233 (1): 200–2. doi:10.1006/bbrc.1997.6433. PMID 9144422.
^ Curran MP (2009). "Bimatoprost: a review of its use in open-angle glaucoma and ocular hypertension". Drugs Aging
26 (12): 1049–71. doi:10.2165/11203210-000000000-00000. PMID 19929032.
^ "Long Lashes Without Prescription, but With Risks". Catherine Saint Louis. The New York Times. May 1, 2010
^ "Potentially Harmful "Cosmetic" Eye Product Seized" (Press release). U.S. Food and Drug Administration (FDA).
November 19, 2007. Retrieved 2007-12-05.
Chen M, Cheng C, Chen Y, Chou C, Hsu W (2006). "Effects of bimatoprost 0.03% on ocular hemodynamics in normal
tension glaucoma.". J Ocul Pharmacol Ther 22 (3): 188–93. doi:10.1089/jop.2006.22.188. PMID 16808680.
Kruse P, Rieck P, Sherif Z, Liekfeld A (2006). "Cystoid macular edema in a pseudophakic patient after several
glaucoma procedures. Is local therapy with bimatoprost the reason?". Klin Monatsbl Augenheilkd 223 (6): 534–7.
doi:10.1055/s-2005-858992. PMID 16804825.
Steinhäuser S (2006). "Decreased high-density lipoprotein serum levels associated with topical bimatoprost
therapy.". Optometry 77 (4): 177–9. doi:10.1016/j.optm.2006.02.001. PMID 16567279.
Medical News Today: FDA Seizes $2 Million Of Cosmetic Eye Product Which Contains Drug Ingredient And Makes
Unapproved Drug Claims. Christian Nordqvist. 18 November 2007
Wired Science: FDA Seizes Cosmetic That Can Blind. Brandon Keim. November 19, 2007
Women have been using various products to enhance the appearance of their eyelashes, creating the illusion that
they are longer, darker, and fuller that they really are. Women have also used tattooing and eyebrow pencil to give
the look of a full eyebrow. Today added to the number of cosmetic products, is are several products that claim to
lengthen, thicken and darken eyelashes. Discover the benefits of one of these products when you read the Idol Lash
It does not matter if your eyelashes are brittle and dry, or extremely space, Idol Lash will help grow new
eyelashes that are longer, thicker, and darker in about two to four weeks of use. This all natural, non irritating
liquid product also comes with the clinical study results to support its claim.
To use this product, it is applied to the eyelid similar to how you would apply liquid eyeliner. Because the
ingredients are all natural, they cause no irritation to the eyes or skin. A number of other eyelash growing
products that contain chemicals that can cause harm, irritate the eyes and skin.
Studies show there is an eighty two percent improvement in the appearance of the lashes with twenty five percent
increase in length in two to four weeks. Results will vary, however the studies show an obvious difference was
noticed in the eyebrows and lashes within the two to four week time period. Even better results were observed after
the seventh week of using the product.
These studies have also proven the product to be safer that other products on the market that use chemicals to
promote eyelash growth. In fact there have been no complaints of irritation or other side effects from using the
serum. With that said it is always a good idea to conduct a skin test to make sure you will not have any type of
reactions from the product. With this product it is now possible to enhance the eyelashes and eyebrows without
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In addition, all the ingredients are clearly listed on the packaging. The company also offers a thirty day trial
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Compared to the other similar type of treatments on the market, Idol Lash appears to be the lowest priced
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Anyone interested in purchasing a product of this kind to grow darker, longer, thicker eyelashes, should first
read the Idol Lash review before deciding on which product is best. Finally, as always, check with your physician
or eye doctor to be certain that this is an appropriate treatment for you.